I'm a PhD candidate with the MCDBG program and master's candidate with BICB, advised by Dr. Matthew Gill and co-advised by Dr. Chad Myers. Because aging and life extension are such complicated processes, and honing in on a single target is so challenging, I am taking a phenotype-centric approach to drug discovery for aging with C. elegans for my thesis project. On one front, I have developed a scalable, deep-learning based imaging assay to screen for drugs that increase heat stress resistance (a predictor of longevity) in worms. My other focus is utilizing pro-longevity drug data to build predictive machine-learning models to find more optimal drugs from large chemical spaces. My broader long-term goal is to discover or engineer interventions that can extend human lifespan and health above baseline.

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Tom Hodder